Association of early maternal hypertriglyceridemia with pregnancy-induced hypertension.
Arch Gynecol Obstet
; 292(5): 1135-43, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-25855054
ABSTRACT
BACKGROUND:
Hypertensive diseases are directly responsible for 24 % of maternal deaths in India. A screening method is yet to be discovered to reduce the morbidity and mortality related to it. Serum triglyceride (TG) levels are reported to increase in hypertensive pregnant women.AIM:
To predict pregnancy-induced hypertension (PIH) by serum triglyceride values.METHOD:
This study is a prospective cohort study that was conducted over three hundred normotensive, primigravida women with singleton pregnancy at 14-20 weeks of gestation. These were divided into two groups on the basis of their TG concentration estimated at 14-20 weeks of gestation. The pregnancy was then followed till delivery and, signs and symptoms of PIH were noted in both the groups.RESULTS:
Out of 300 women, 210 women completed the study. Fifty-nine women developed PIH and 151 women remained normotensive. Among 59 women, 45 women had raised TG values i.e., ≥160 mg/dL and 14 women were with normal TG levels i.e., <160 mg/dL. A significant positive correlation was found between serum TG concentration and systolic and diastolic blood pressure. It was observed that a cutoff of 162.50 mg/dL for TG could reliably predict PIH with sensitivity of 76 % and specificity of 85 %. Also, the mothers with hypertriglyceridemia were found to be at higher risk of developing early-onset PIH.CONCLUSION:
Our study supports the evidence that early pregnancy hypertriglyceridemia is associated with an increased risk of PIH.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hipertrigliceridemia
/
Hipertensão Induzida pela Gravidez
Tipo de estudo:
Etiology_studies
/
Incidence_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Pregnancy
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article