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Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.
Theodoulou, Natalie H; Bamborough, Paul; Bannister, Andrew J; Becher, Isabelle; Bit, Rino A; Che, Ka Hing; Chung, Chun-wa; Dittmann, Antje; Drewes, Gerard; Drewry, David H; Gordon, Laurie; Grandi, Paola; Leveridge, Melanie; Lindon, Matthew; Michon, Anne-Marie; Molnar, Judit; Robson, Samuel C; Tomkinson, Nicholas C O; Kouzarides, Tony; Prinjha, Rab K; Humphreys, Philip G.
Afiliação
  • Theodoulou NH; Epinova Discovery Performance Unit, GlaxoSmithKline R&D , Stevenage, Hertfordshire SG1 2NY, U.K.
  • Bamborough P; WestCHEM, Department of Pure and Applied Chemistry, Thomas Graham Building, University of Strathclyde , 295 Cathedral Street, Glasgow G1 1XL, U.K.
  • Bannister AJ; Computational & Structural Chemistry, Molecular Discovery Research, GlaxoSmithKline R&D , Stevenage, Hertfordshire SG1 2NY, U.K.
  • Becher I; Department of Pathology, Gurdon Institute , Tennis Court Road, Cambridge CB2 1QN, U.K.
  • Bit RA; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline R&D , Meyerhofstrasse 1, 69117 Heidelberg, Germany.
  • Che KH; Epinova Discovery Performance Unit, GlaxoSmithKline R&D , Stevenage, Hertfordshire SG1 2NY, U.K.
  • Chung CW; Department of Pathology, Gurdon Institute , Tennis Court Road, Cambridge CB2 1QN, U.K.
  • Dittmann A; Computational & Structural Chemistry, Molecular Discovery Research, GlaxoSmithKline R&D , Stevenage, Hertfordshire SG1 2NY, U.K.
  • Drewes G; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline R&D , Meyerhofstrasse 1, 69117 Heidelberg, Germany.
  • Drewry DH; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline R&D , Meyerhofstrasse 1, 69117 Heidelberg, Germany.
  • Gordon L; Department of Chemical Biology, GlaxoSmithKline , Research Triangle Park, North Carolina 27709, United States.
  • Grandi P; Biological Sciences, Molecular Discovery Research, GlaxoSmithKline R&D , Stevenage, Hertfordshire SG1 2NY, U.K.
  • Leveridge M; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline R&D , Meyerhofstrasse 1, 69117 Heidelberg, Germany.
  • Lindon M; Biological Sciences, Molecular Discovery Research, GlaxoSmithKline R&D , Stevenage, Hertfordshire SG1 2NY, U.K.
  • Michon AM; Epinova Discovery Performance Unit, GlaxoSmithKline R&D , Stevenage, Hertfordshire SG1 2NY, U.K.
  • Molnar J; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline R&D , Meyerhofstrasse 1, 69117 Heidelberg, Germany.
  • Robson SC; Epinova Discovery Performance Unit, GlaxoSmithKline R&D , Stevenage, Hertfordshire SG1 2NY, U.K.
  • Tomkinson NC; Department of Pathology, Gurdon Institute , Tennis Court Road, Cambridge CB2 1QN, U.K.
  • Kouzarides T; WestCHEM, Department of Pure and Applied Chemistry, Thomas Graham Building, University of Strathclyde , 295 Cathedral Street, Glasgow G1 1XL, U.K.
  • Prinjha RK; Department of Pathology, Gurdon Institute , Tennis Court Road, Cambridge CB2 1QN, U.K.
  • Humphreys PG; Epinova Discovery Performance Unit, GlaxoSmithKline R&D , Stevenage, Hertfordshire SG1 2NY, U.K.
J Med Chem ; 59(4): 1425-39, 2016 Feb 25.
Article em En | MEDLINE | ID: mdl-25856009
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Bibliotecas de Moléculas Pequenas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Bibliotecas de Moléculas Pequenas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article