Distribution of lymphocyte subpopulations in patients with polycythemia vera.
Hum Immunol
; 76(6): 414-6, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25858863
ABSTRACT
Polycythemia vera (PV) is a disease with slow development. Nonetheless, the immune response is unable to eliminate the uncontrolled proliferating hematopoietic cells, leading to treatment of patient by phlebotomy and/or cytotoxic drugs. In addition, a higher incidence of cancers is observed in PV patients, independently of treatment. These observations argue for an impaired immune response in PV. In order to investigate this hypothesis, we studied the distribution of lymphocyte subpopulations in PV, and showed a significant decrease in T, TCR γ/δ and B cells together with an increase in natural killer (NK) cells.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Policitemia Vera
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Células Matadoras Naturais
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Subpopulações de Linfócitos B
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Subpopulações de Linfócitos T
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article