Hepatoprotective triterpene saponins from the roots of Glycyrrhiza inflata.
Molecules
; 20(4): 6273-83, 2015 Apr 09.
Article
em En
| MEDLINE
| ID: mdl-25859783
ABSTRACT
Two novel oleanane-type triterpene saponins, licorice-saponin P2 (1) and licorice-saponin Q2 (3), together with nine known compounds 2, 4-11, have been isolated from the water extract of the roots of Glycyrrhiza inflata. The structures of these compounds were elucidated on the basis of spectroscopic analysis, including 2D-NMR experiments (1H-1H COSY, HSQC, HMBC and ROESY). In in vitro assays, compounds 2-4, 6 and 11 showed significant hepatoprotective activities by lowering the ALT and AST levels in primary rat hepatocytes injured by D-galactosamine (D-GalN). In addition, compounds 2-4, 6, 7 and 11 were found to inhibit the activity of PLA2 with IC50 values of 6.9 µM, 3.6 µM, 16.9 µM, 27.1 µM, 32.2 µM and 9.3 µM, respectively, which might be involved in the regulation of the hepatoprotective activities observed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Saponinas
/
Triterpenos
/
Glycyrrhiza
/
Fígado
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article