HPV-negative squamous cell carcinoma of the anal canal is unresponsive to standard treatment and frequently carries disruptive mutations in TP53.

Meulendijks, D; Tomasoa, N B; Dewit, L; Smits, P H M; Bakker, R; van Velthuysen, M-L F; Rosenberg, E H; Beijnen, J H; Schellens, J H M; Cats, A

Meulendijks, D; Tomasoa, N B; Dewit, L; Smits, P H M; Bakker, R; van Velthuysen, M-L F; Rosenberg, E H; Beijnen, J H; Schellens, J H M; Cats, A.

Afiliação

Meulendijks D; 1] Division of Clinical Pharmacology, Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands [2] Department of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands [3] Division of Gastroenterology and Hepatology, Department of Medica
Tomasoa NB; Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Dewit L; Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Smits PH; Department of Molecular Biology, Slotervaart Hospital, Amsterdam, The Netherlands.
Bakker R; Department of Molecular Biology, Slotervaart Hospital, Amsterdam, The Netherlands.
van Velthuysen ML; Department of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Rosenberg EH; Department of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Beijnen JH; 1] Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands [2] Faculty of Science, Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Schellens JH; 1] Division of Clinical Pharmacology, Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands [2] Department of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands [3] Faculty of Science, Division of Pharmacoepidemiology and Clinical
Cats A; Division of Gastroenterology and Hepatology, Department of Medical Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands.

Br J Cancer ; 112(8): 1358-66, 2015 Apr 14.

Article em En | MEDLINE | ID: mdl-25871546

Assuntos

Alphapapillomavirus/isolamento & purificação; Neoplasias do Ânus/terapia; Carcinoma de Células Escamosas/terapia; Proteína Supressora de Tumor p53/genética; Adulto; Idoso; Idoso de 80 Anos ou mais; Alphapapillomavirus/classificação; Neoplasias do Ânus/genética; Neoplasias do Ânus/virologia; Carcinoma de Células Escamosas/genética; Carcinoma de Células Escamosas/virologia; Inibidor p16 de Quinase Dependente de Ciclina/metabolismo; Tratamento Farmacológico; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Mutação; Infecções por Papillomavirus/genética; Infecções por Papillomavirus/virologia; Radioterapia; Resultado do Tratamento

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Ânus / Carcinoma de Células Escamosas / Proteína Supressora de Tumor p53 / Alphapapillomavirus Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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