Positive Direct Immunofluorescence Is of Better Value than ELISA-BP180 and ELISA-BP230 Values for the Prediction of Relapse after Treatment Cessation in Bullous Pemphigoid: A Retrospective Study of 97 Patients.
Dermatology
; 231(1): 50-5, 2015.
Article
em En
| MEDLINE
| ID: mdl-25871736
ABSTRACT
BACKGROUND:
ELISA-BP180 values and direct immunofluorescence (DIF) are prognostic factors for relapse after treatment cessation in bullous pemphigoid (BP).OBJECTIVE:
To determine the relevance of ELISA-BP230 antibodies for predicting relapse 6 months after treatment cessation.METHODS:
We retrospectively selected patients with BP and available data from ELISA-BP180 and -BP230 and DIF performed at treatment cessation. The rate of relapse was calculated at 6 months. We compared ELISA-BP180 and -BP230 values and DIF in patients with relapse and remission.RESULTS:
We included 97 patients. At 6 months, 25.6% of patients showed relapse. The proportion of patients with an ELISA-BP230 value ≥27 UA/ml was higher, but not significantly, for those with relapse than for those with remission (p = 0.11). The frequency of positive DIF findings was significantly higher for patients with relapse (p = 0.005).CONCLUSION:
DIF is of better value than ELISA-BP180 and -230 tests to predict relapse after treatment cessation in BP.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
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Autoantígenos
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Proteínas de Transporte
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Penfigoide Bolhoso
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Proteínas do Citoesqueleto
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Colágenos não Fibrilares
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Proteínas do Tecido Nervoso
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article