[Distribution in early mouse embryos of foreign mtDNA transmitted along the paternal lineage].

Transmission of foreign mtDNA along the paternal lineage founded by male mice (F0), and distribution of that mtDNA in their progeny at early stages of prenatal development were studied. Transmitochondrial males of F0 obtained after injection of human mitochondria into mouse zygotes has been shown to transmit foreign mtDNA to subsequent generations. Individual peculiarities among the males studied, concerning transmission of foreign mtDNA to the progeny, are likely to exist. Besides, the distribution of human mtDNA among blastomeres of transmitochondrial embryos under study differed from that observed in previous investogation of its inheritance along the maternal lineage.