Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways.

Wei, Qiong; Liu, Haijuan; Zhou, Honghao; Zhang, Dejun; Zhang, Zhiwei; Zhou, Qibing

Wei, Qiong; Liu, Haijuan; Zhou, Honghao; Zhang, Dejun; Zhang, Zhiwei; Zhou, Qibing.

Afiliação

Wei Q; Department of Nanomedicine & Biopharmaceuticals, National Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, Wuhan, Hubei, China. 429791916@qq.com.
Liu H; Department of Nanomedicine & Biopharmaceuticals, National Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, Wuhan, Hubei, China. liuhaijuan1990@163.com.
Zhou H; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. 267411664@qq.com.
Zhang D; Department of Nanomedicine & Biopharmaceuticals, National Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, Wuhan, Hubei, China. 516043259@qq.com.
Zhang Z; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. zwzhang38@hotmail.com.
Zhou Q; Department of Nanomedicine & Biopharmaceuticals, National Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, Wuhan, Hubei, China. qibingzhou@hust.edu.cn.

BMC Cancer ; 15: 159, 2015 Mar 21.

Article em En | MEDLINE | ID: mdl-25881156

Assuntos

Antineoplásicos/metabolismo; Antineoplásicos/farmacologia; Redes e Vias Metabólicas; Quinoxalinas/metabolismo; Quinoxalinas/farmacologia; Timidina/metabolismo; Animais; Antineoplásicos/toxicidade; Linhagem Celular Tumoral; Citosol/metabolismo; Modelos Animais de Doenças; Expressão Gênica; Inativação Gênica; Humanos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patologia; Masculino; Camundongos; Neoplasias/metabolismo; Quinoxalinas/toxicidade; Timidina Quinase/genética; Timidina Quinase/metabolismo; Timidina Fosforilase/genética; Timidina Fosforilase/metabolismo; Carga Tumoral/efeitos dos fármacos; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinoxalinas / Timidina / Redes e Vias Metabólicas / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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