New insights into the molecular and epigenetic effects of antitumor Pt(IV)-valproic acid conjugates in human ovarian cancer cells.

Novohradsky, Vojtech; Zerzankova, Lenka; Stepankova, Jana; Vrana, Oldrich; Raveendran, Raji; Gibson, Dan; Kasparkova, Jana; Brabec, Viktor

Novohradsky, Vojtech; Zerzankova, Lenka; Stepankova, Jana; Vrana, Oldrich; Raveendran, Raji; Gibson, Dan; Kasparkova, Jana; Brabec, Viktor.

Afiliação

Novohradsky V; Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Kralovopolska 135, CZ-61265 Brno, Czech Republic.
Zerzankova L; Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Kralovopolska 135, CZ-61265 Brno, Czech Republic.
Stepankova J; Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Kralovopolska 135, CZ-61265 Brno, Czech Republic.
Vrana O; Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Kralovopolska 135, CZ-61265 Brno, Czech Republic.
Raveendran R; Institute for Drug Research, School of Pharmacy, The Hebrew University, Jerusalem 91120, Israel.
Gibson D; Institute for Drug Research, School of Pharmacy, The Hebrew University, Jerusalem 91120, Israel.
Kasparkova J; Department of Biophysics, Faculty of Science, Palacky University, 17. listopadu 12, CZ-77146 Olomouc, Czech Republic.
Brabec V; Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Kralovopolska 135, CZ-61265 Brno, Czech Republic. Electronic address: brabec@ibp.cz.

Biochem Pharmacol ; 95(3): 133-44, 2015 Jun 01.

Article em En | MEDLINE | ID: mdl-25888926

Assuntos

Epigênese Genética; Compostos Organoplatínicos/metabolismo; Neoplasias Ovarianas/metabolismo; Ácido Valproico/metabolismo; Acetilação; Linhagem Celular Tumoral; Feminino; Glutationa/metabolismo; Histona Desacetilases/metabolismo; Histonas/metabolismo; Humanos; Espectroscopia de Ressonância Magnética; Compostos Organoplatínicos/química; Neoplasias Ovarianas/genética; Neoplasias Ovarianas/patologia; Ácido Valproico/química

Palavras-chave

Cellular accumulation; Chromatin decondensation; Cytotoxicity; Glutathione; Histone deacetylase inhibition; Platinum-valproic acid conjugates

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos Organoplatínicos / Neoplasias Ovarianas / Ácido Valproico / Epigênese Genética Limite: Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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