Tertiary amides of Salinomycin: A new group of antibacterial agents against Bacillus anthracis and methicillin-resistant Staphylococcus epidermidis.
Bioorg Med Chem Lett
; 25(10): 2082-8, 2015.
Article
em En
| MEDLINE
| ID: mdl-25891104
ABSTRACT
For the first time, a series of tertiary amides of polyether antibiotic-Salinomycin have been obtained and screened for their antibacterial activity against different strains of bacteria, including Bacillus anthracis and clinical methicillin-resistant Staphylococcus epidermidis (MRSE). Moreover, biofilm inhibition of MRSE and genotoxicity tests against Bacillus subtilis have been performed. Our studies show that Salinomycin and its some derivatives are active against tested bacteria and exhibited definitely bacteriostatic, not bactericidal activity.
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Base de dados:
MEDLINE
Assunto principal:
Piranos
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Staphylococcus epidermidis
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Bacillus anthracis
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Amidas
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Antibacterianos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article