[Stable analogues of coenzyme-substrate complex of spermidine/spermine-N1-acetyltransferase reaction. synthesis, interaction with the enzyme].
Bioorg Khim
; 40(2): 170-7, 2014.
Article
em Ru
| MEDLINE
| ID: mdl-25895336
ABSTRACT
Convenient two-step synthesis of conjugates of HS-CoA and D-pantetheine with aminooxy analogues of Spm, Spd and Put was suggested. The use of acetone linker provided target conjugates with quantitative yields. The activity of CoA-derived "bisubstrate" inhibitors being active at microM concentrations was at least 100 times better than that of corresponding derivatives of D-pantetheine.
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Base de dados:
MEDLINE
Assunto principal:
Poliaminas
/
Acetiltransferases
/
Espermidina
/
Espermina
Idioma:
Ru
Ano de publicação:
2014
Tipo de documento:
Article