Oncogenic NRAS Primes Primary Acute Myeloid Leukemia Cells for Differentiation.

Brendel, Cornelia; Teichler, Sabine; Millahn, Axel; Stiewe, Thorsten; Krause, Michael; Stabla, Kathleen; Ross, Petra; Huynh, Minh; Illmer, Thomas; Mernberger, Marco; Barckhausen, Christina; Neubauer, Andreas

Brendel, Cornelia; Teichler, Sabine; Millahn, Axel; Stiewe, Thorsten; Krause, Michael; Stabla, Kathleen; Ross, Petra; Huynh, Minh; Illmer, Thomas; Mernberger, Marco; Barckhausen, Christina; Neubauer, Andreas.

Afiliação

Brendel C; Department of Hematology, Oncology and Immunology, Philipps University of Marburg, and University Clinic Giessen and Marburg, Marburg, Germany.
Teichler S; Department of Hematology, Oncology and Immunology, Philipps University of Marburg, and University Clinic Giessen and Marburg, Marburg, Germany.
Millahn A; Department of Hematology, Oncology and Immunology, Philipps University of Marburg, and University Clinic Giessen and Marburg, Marburg, Germany.
Stiewe T; Molecular Oncology, Philipps University of Marburg, Marburg, Germany.
Krause M; Molecular Oncology, Philipps University of Marburg, Marburg, Germany.
Stabla K; Department of Hematology, Oncology and Immunology, Philipps University of Marburg, and University Clinic Giessen and Marburg, Marburg, Germany.
Ross P; Department of Hematology, Oncology and Immunology, Philipps University of Marburg, and University Clinic Giessen and Marburg, Marburg, Germany.
Huynh M; Department of Hematology, Oncology and Immunology, Philipps University of Marburg, and University Clinic Giessen and Marburg, Marburg, Germany.
Illmer T; Medical Clinic I, University Clinic of Technical University Dresden, Dresden, Germany.
Mernberger M; Molecular Oncology, Philipps University of Marburg, Marburg, Germany.
Barckhausen C; Department of Hematology, Oncology and Immunology, Philipps University of Marburg, and University Clinic Giessen and Marburg, Marburg, Germany.
Neubauer A; Department of Hematology, Oncology and Immunology, Philipps University of Marburg, and University Clinic Giessen and Marburg, Marburg, Germany.

PLoS One ; 10(4): e0123181, 2015.

Article em En | MEDLINE | ID: mdl-25901794

Assuntos

Diferenciação Celular; GTP Fosfo-Hidrolases/metabolismo; Leucemia Mieloide Aguda/patologia; Proteínas de Membrana/metabolismo; Idoso; Diferenciação Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Estudos de Coortes; Citarabina/farmacologia; Citarabina/uso terapêutico; Feminino; GTP Fosfo-Hidrolases/genética; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Proteínas de Homeodomínio/genética; Humanos; Leucemia Mieloide Aguda/tratamento farmacológico; Leucemia Mieloide Aguda/genética; Masculino; Proteínas de Membrana/genética; Pessoa de Meia-Idade; Mutação; Células Mieloides/efeitos dos fármacos; Células Mieloides/patologia; Proteína Meis1; Proteínas de Neoplasias/genética; Proteínas de Fusão Oncogênica/genética; Proteínas ras/genética; Proteínas ras/metabolismo

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Diferenciação Celular / GTP Fosfo-Hidrolases / Proteínas de Membrana Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google