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Circulating immune/inflammation markers in Chinese workers occupationally exposed to formaldehyde.
Seow, Wei Jie; Zhang, Luoping; Vermeulen, Roel; Tang, Xiaojiang; Hu, Wei; Bassig, Bryan A; Ji, Zhiying; Shiels, Meredith S; Kemp, Troy J; Shen, Min; Qiu, Chuangyi; Reiss, Boris; Beane Freeman, Laura E; Blair, Aaron; Kim, Christopher; Guo, Weihong; Wen, Cuiju; Li, Laiyu; Pinto, Ligia A; Huang, Hanlin; Smith, Martyn T; Hildesheim, Allan; Rothman, Nathaniel; Lan, Qing.
Afiliação
  • Seow WJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA, Division of Environmental Epidemiology, Institute for Ris
  • Zhang L; Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
  • Vermeulen R; Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
  • Tang X; Guangdong Poison Control Center, Guangzhou, China, and.
  • Hu W; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA, Division of Environmental Epidemiology, Institute for Ris
  • Bassig BA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA, Division of Environmental Epidemiology, Institute for Ris
  • Ji Z; Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
  • Shiels MS; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA, Division of Environmental Epidemiology, Institute for Ris
  • Kemp TJ; HPV Immunology Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Shen M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA, Division of Environmental Epidemiology, Institute for Ris
  • Qiu C; Guangdong Poison Control Center, Guangzhou, China, and.
  • Reiss B; Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
  • Beane Freeman LE; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA, Division of Environmental Epidemiology, Institute for Ris
  • Blair A; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA, Division of Environmental Epidemiology, Institute for Ris
  • Kim C; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA, Division of Environmental Epidemiology, Institute for Ris
  • Guo W; Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
  • Wen C; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA, Division of Environmental Epidemiology, Institute for Ris
  • Li L; Guangdong Poison Control Center, Guangzhou, China, and.
  • Pinto LA; HPV Immunology Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Huang H; Guangdong Poison Control Center, Guangzhou, China, and.
  • Smith MT; Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
  • Hildesheim A; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA, Division of Environmental Epidemiology, Institute for Ris
  • Rothman N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA, Division of Environmental Epidemiology, Institute for Ris
  • Lan Q; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA, Division of Environmental Epidemiology, Institute for Ris
Carcinogenesis ; 36(8): 852-7, 2015 Aug.
Article em En | MEDLINE | ID: mdl-25908645
BACKGROUND: Formaldehyde has been classified as a human myeloid leukemogen. However, the mechanistic basis for this association is still debated. OBJECTIVES: We aimed to evaluate whether circulating immune/inflammation markers were altered in workers occupationally exposed to formaldehyde. METHODS: Using a multiplexed bead-based assay, we measured serum levels of 38 immune/inflammation markers in a cross-sectional study of 43 formaldehyde-exposed and 51 unexposed factory workers in Guangdong, China. Linear regression models adjusting for potential confounders were used to compare marker levels in exposed and unexposed workers. RESULTS: We found significantly lower circulating levels of two markers among exposed factory workers compared with unexposed controls that remained significant after adjusting for potential confounders and multiple comparisons using a false discovery rate of 10%, including chemokine (C-X-C motif) ligand 11 (36.2 pg/ml in exposed versus 48.4 pg/ml in controls, P = 0.0008) and thymus and activation regulated chemokine (52.7 pg/ml in exposed versus 75.0 pg/ml in controls, P = 0.0028), suggesting immunosuppression among formaldehyde-exposed workers. CONCLUSIONS: Our findings are consistent with recently emerging understanding that immunosuppression might be associated with myeloid diseases. These findings, if replicated in a larger study, may provide insights into the mechanisms by which formaldehyde promotes leukemogenesis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores / Exposição Ocupacional / Formaldeído / Inflamação Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País como assunto: Asia Idioma: En Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores / Exposição Ocupacional / Formaldeído / Inflamação Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País como assunto: Asia Idioma: En Ano de publicação: 2015 Tipo de documento: Article