N-Heterocyclic Carbene-Catalyzed δ-Carbon LUMO Activation of Unsaturated Aldehydes.
J Am Chem Soc
; 137(17): 5658-61, 2015 May 06.
Article
em En
| MEDLINE
| ID: mdl-25910417
ABSTRACT
An N-heterocyclic carbene (NHC) catalyzed domino reaction triggered by a δ-LUMO activation of α,ß-γ,δ-diunsaturated enal has been developed for the formal [4 + 2] construction of multisubstituted arenes and 3-ylidenephthalide. These two products, formed in a highly chemo- and regioselective manner, were obtained via different catalytic pathways due to a simple change of the substrate. The activation of the remote δ-carbon of unsaturated aldehydes expands the synthetic potentials of NHC organocatalysis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carbono
/
Aldeídos
/
Compostos Heterocíclicos
/
Metano
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article