Structural studies and cytotoxicity assays of "aggregation-prone" IAPP(8-16) and its non-amyloidogenic variants suggest its important role in fibrillogenesis and cytotoxicity of human amylin.

Louros, Nikolaos N; Tsiolaki, Paraskevi L; Zompra, Aikaterini A; Pappa, Eleni V; Magafa, Vassiliki; Pairas, George; Cordopatis, Paul; Cheimonidou, Christina; Trougakos, Ioannis P; Iconomidou, Vassiliki A; Hamodrakas, Stavros J

Louros, Nikolaos N; Tsiolaki, Paraskevi L; Zompra, Aikaterini A; Pappa, Eleni V; Magafa, Vassiliki; Pairas, George; Cordopatis, Paul; Cheimonidou, Christina; Trougakos, Ioannis P; Iconomidou, Vassiliki A; Hamodrakas, Stavros J.

Afiliação

Louros NN; Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, 157 01, Greece.
Tsiolaki PL; Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, 157 01, Greece.
Zompra AA; Department of Pharmacy, University of Patras, Patras, 26504, Greece.
Pappa EV; Department of Pharmacy, University of Patras, Patras, 26504, Greece.
Magafa V; Department of Pharmacy, University of Patras, Patras, 26504, Greece.
Pairas G; Department of Pharmacy, University of Patras, Patras, 26504, Greece.
Cordopatis P; Department of Pharmacy, University of Patras, Patras, 26504, Greece.
Cheimonidou C; Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, 157 01, Greece.
Trougakos IP; Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, 157 01, Greece.
Iconomidou VA; Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, 157 01, Greece.
Hamodrakas SJ; Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, 157 01, Greece.

Biopolymers ; 104(3): 196-205, 2015 May.

Article em En | MEDLINE | ID: mdl-25913357

Assuntos

Citotoxinas; Polipeptídeo Amiloide das Ilhotas Pancreáticas; Peptídeos; Agregados Proteicos; Linhagem Celular; Citotoxinas/síntese química; Citotoxinas/química; Citotoxinas/farmacologia; Humanos; Polipeptídeo Amiloide das Ilhotas Pancreáticas/química; Polipeptídeo Amiloide das Ilhotas Pancreáticas/farmacologia; Peptídeos/síntese química; Peptídeos/química; Peptídeos/farmacologia

Palavras-chave

amylin; amyloid fibrils; cytotoxicity assays; islet amyloid polypeptide (IAPP); peptide analogs; type II diabetes mellitus

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Citotoxinas / Polipeptídeo Amiloide das Ilhotas Pancreáticas / Agregados Proteicos Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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