Signaling mechanisms mediating the regulation of synaptic plasticity and memory by estradiol.
Horm Behav
; 74: 19-27, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-25921586
ABSTRACT
This article is part of a Special Issue "Estradiol and Cognition". Estradiol participates in the regulation of the function and plasticity of synaptic circuits in key cognitive brain regions, such as the prefrontal cortex and the hippocampus. The mechanisms elicited by estradiol are mediated by the regulation of transcriptional activity by nuclear estrogen receptors and by intracellular signaling cascades activated by estrogen receptors associated with the plasma membrane. In addition, the mechanisms include the interaction of estradiol with the signaling of other factors involved in the regulation of cognition, such as brain derived neurotrophic factor, insulin-like growth factor-1 and Wnt. Modifications in these signaling pathways by aging or by a long-lasting ovarian hormone deprivation after menopause may impair the enhancing effects of estradiol on synaptic plasticity and cognition.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estradiol
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Memória
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Plasticidade Neuronal
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article