Building blocks of the cerebral cortex: from development to the dish.
Wiley Interdiscip Rev Dev Biol
; 4(5): 529-44, 2015.
Article
em En
| MEDLINE
| ID: mdl-25926310
ABSTRACT
Since Ramon y Cajal's examination of the cellular makeup of the cerebral cortex, it has been appreciated that this tissue exhibits some of the greatest degrees of cellular heterogeneity in the entire nervous system. This intricate structure emerges during a well-choreographed developmental process. Here, we review current classifications of the cellular constituents of the cerebral cortex and examine how these building blocks are forged during development. We also look at how basic developmental features underlying cortex formation in vivo have been applied to protocols aimed at generating cortical tissue in vitro.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Córtex Cerebral
/
Neurogênese
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article