Intermediate-grade meningeal melanocytoma associated with nevus of Ota: a case report and review of the literature.
Melanoma Res
; 25(4): 273-8, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-25933209
ABSTRACT
Meningeal melanocytomas are rare melanin-producing tumors that are often found to be benign. However, a small subset of these tumors can present as intermediate-grade melanocytomas (IGMs) that have histopathological features that are between those of benign melanocytomas and malignant melanomas. IGMs have the potential to recur and metastasize or progress to a more histologically high grade melanoma. Melanocytomas appear to differ from primary and metastatic melanoma by their prolonged clinical course and they appear to have different driver mutations (i.e. mutation of GNAQ gene). The association of a meningeal melanocytoma with nevus of Ota is extremely rare. To our knowledge, there have been only 10 reported cases of synchronous occurrence and only one of the cases involved an IGM. We report the second case of intermediate-grade meningeal melanocytoma that is associated with congenital nevus of Ota. Histopathological work-up confirmed the intermediate grade of the lesion and a driver GNAQ mutation was identified consistent with previous reports.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nevo de Ota
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Subunidades alfa de Proteínas de Ligação ao GTP
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Melanócitos
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Melanoma
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Neoplasias Meníngeas
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article