Determination of MIC distribution and epidemiological cutoff values for bedaquiline and delamanid in Mycobacterium tuberculosis using the MGIT 960 system equipped with TB eXiST.
Antimicrob Agents Chemother
; 59(7): 4352-5, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-25941226
ABSTRACT
Bedaquiline (Sirturo) and delamanid (Deltyba) have recently been approved by the regulatory authorities for treatment of multidrug-resistant tuberculosis (MDR-TB). Antimicrobial susceptibility testing is not established for either substance. On the basis of the use of the MGIT 960 system equipped with EpiCenter/TB eXiST, we determined a mean bedaquiline MIC for wild-type strains of 0.65 mg/liter (median, 0.4 mg/liter) and an epidemiological cutoff (ECOFF) of 1.6 mg/liter; for delamanid, a mean wild-type drug MIC of 0.013 mg/liter (median, 0.01 mg/liter) and an ECOFF of 0.04 mg/liter were determined.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Oxazóis
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Testes de Sensibilidade Microbiana
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Diarilquinolinas
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Mycobacterium tuberculosis
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Nitroimidazóis
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Antituberculosos
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article