STAT1-S727 - the license to kill.

Putz, Eva M; Gotthardt, Dagmar; Sexl, Veronika.

Afiliação

Putz EM; Institute of Pharmacology and Toxicology; University of Veterinary Medicine Vienna ; Vienna, Austria.
Gotthardt D; Institute of Pharmacology and Toxicology; University of Veterinary Medicine Vienna ; Vienna, Austria.
Sexl V; Institute of Pharmacology and Toxicology; University of Veterinary Medicine Vienna ; Vienna, Austria.

Oncoimmunology ; 3(9): e955441, 2014 Oct.

Article em En | MEDLINE | ID: mdl-25941617

ABSTRACT

Serine phosphorylation has generally been considered indispensable for full transcriptional activity of STAT proteins. Recent data indicate that CDK8-mediated phosphorylation of signal transducer and activator of transcription 1 (STAT1) on S727 inhibits natural killer (NK) cell cytotoxicity and restrains tumor surveillance. These findings implicate CDK8 as a promising target for immunotherapy.

Palavras-chave

CDK, cyclin-dependent kinase; CDK8; CTLA-4, cytotoxic T lymphocyte antigen 4; FDA, food and drug administration; KLRG1, killer cell lectin-like receptor subfamily G member 1; MHC, major histocompatibility complex; NK cells; NK, natural killer; PD-1, programmed cell death 1; STAT1; STAT1, signal transducer and activator of transcription 1; immunotherapy; tumor immune surveillance

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2014 Tipo de documento: Article