FlyNet: a versatile network prioritization server for the Drosophila community.
Nucleic Acids Res
; 43(W1): W91-7, 2015 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-25943544
ABSTRACT
Drosophila melanogaster (fruit fly) has been a popular model organism in animal genetics due to the high accessibility of reverse-genetics tools. In addition, the close relationship between the Drosophila and human genomes rationalizes the use of Drosophila as an invertebrate model for human neurobiology and disease research. A platform technology for predicting candidate genes or functions would further enhance the usefulness of this long-established model organism for gene-to-phenotype mapping. Recently, the power of network prioritization for gene-to-phenotype mapping has been demonstrated in many organisms. Here we present a network prioritization server dedicated to Drosophila that covers â¼95% of the coding genome. This server, dubbed FlyNet, has several distinctive features, including (i) prioritization for both genes and functions; (ii) two complementary network algorithms direct neighborhood and network diffusion; (iii) spatiotemporal-specific networks as an additional prioritization strategy for traits associated with a specific developmental stage or tissue and (iv) prioritization for human disease genes. FlyNet is expected to serve as a versatile hypothesis-generation platform for genes and functions in the study of basic animal genetics, developmental biology and human disease. FlyNet is available for free at http//www.inetbio.org/flynet.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Software
/
Drosophila melanogaster
/
Redes Reguladoras de Genes
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article