DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response.

Zhong, Li; Chen, Xiao-Fen; Zhang, Zhen-Lian; Wang, Zhe; Shi, Xin-Zhen; Xu, Kai; Zhang, Yun-Wu; Xu, Huaxi; Bu, Guojun

Zhong, Li; Chen, Xiao-Fen; Zhang, Zhen-Lian; Wang, Zhe; Shi, Xin-Zhen; Xu, Kai; Zhang, Yun-Wu; Xu, Huaxi; Bu, Guojun.

Afiliação

Zhong L; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen 361102, PR China.
Chen XF; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen 361102, PR China. Electronic address: chenxf@xmu.edu.cn.
Zhang ZL; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen 361102, PR China.
Wang Z; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen 361102, PR China.
Shi XZ; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen 361102, PR China.
Xu K; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen 361102, PR China.
Zhang YW; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen 361102, PR China.
Xu H; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen 361102, PR China; Degenerative Disease Research Program, Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research In
Bu G; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen 361102, PR China; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224. Electronic address: bu.guojun@mayo.edu.

J Biol Chem ; 290(25): 15866-15877, 2015 Jun 19.

Article em En | MEDLINE | ID: mdl-25957402

Assuntos

Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Lipopolissacarídeos/toxicidade; Glicoproteínas de Membrana/metabolismo; Proteínas de Membrana/metabolismo; Receptores Imunológicos/metabolismo; Proteínas Adaptadoras de Transdução de Sinal/genética; Secretases da Proteína Precursora do Amiloide/genética; Secretases da Proteína Precursora do Amiloide/metabolismo; Animais; Células HEK293; Humanos; Inflamação/induzido quimicamente; Inflamação/genética; Inflamação/metabolismo; Inflamação/patologia; Glicoproteínas de Membrana/genética; Proteínas de Membrana/genética; Camundongos; Mutação; Estabilidade Proteica/efeitos dos fármacos; Estrutura Terciária de Proteína; Receptores Imunológicos/genética

Palavras-chave

Alzheimer disease; DAP12; TREM-CTF; TREM2; cytokine; inflammation; lipopolysaccharide (LPS); microglia; Î³-secretase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Receptores Imunológicos / Lipopolissacarídeos / Proteínas Adaptadoras de Transdução de Sinal / Proteínas de Membrana Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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