Compressive mechanical stress may activate IKK-NF-κB through proinflammatory cytokines in MC3T3-E1 cells.
Biotechnol Lett
; 37(9): 1729-35, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-25967035
ABSTRACT
OBJECTIVE:
To determine whether IKK-NF-κB is activated either directly by compressive mechanical stress or by proinflammatory cytokines produced by MC3T3-E1 cells under compressive stress loading.RESULTS:
MC3T3-E1 cells subjected to cyclic uniaxial compressive stress showed increased expression of proinflammatory cytokines and activation of the IKK-NF-κB signaling pathway with nuclear translocation of p65. Following treatment with antibodies to neutralize the action of the proinflammatory cytokines, IL-1ß and IL-6, the activation of IKK-NF-κB signaling was notably inhibited in MC3T3-E1 cells subjected to force loading.CONCLUSION:
IKK-NF-κB signaling in MC3T3-E1 cells may be activated by proinflammatory cytokines that are produced as a consequence of mechanical stress loading and not by direct compressive mechanical stress.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estresse Mecânico
/
Citocinas
/
Proteínas I-kappa B
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article