Non-extracorporeal circulation for coronary artery bypass graft surgery is more beneficial than extracorporeal circulation.
Eur Rev Med Pharmacol Sci
; 19(8): 1452-6, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25967721
ABSTRACT
OBJECTIVE:
The objective of this study was to compare coronary artery bypass graft (CABG) surgery with non-extracorporeal vs. extracorporeal circulation. The study outcomes included operative time, number of graft vessels, pulmonary infection rates, and systemic inflammatory markers. PATIENTS ANDMETHODS:
96 patients received selective CABG, either with non-extracorporeal (study group; n = 48) or extracorporeal circulation (control group; n = 48). Operative time, pulmonary infection rates, and blood levels of inflammatory markers TNF-α, IL-6, and IL-8 before and 4, 24, and 48 hours after the surgery were quantified. Graft vessels were quantified using computed tomography.RESULTS:
Operative time was significantly shorter in study group (4.58 ± 0.91 vs. 5.36 ± 1.12 hours in control group; p < 0.05). The number of graft vessels and pulmonary infection rates were comparable between both techniques. However, systemic inflammatory markers were significantly (p < 0.05) lower in study group at 4 and, partly, 24 hours after the surgery.CONCLUSIONS:
Extracorporeal circulation prolongs operation and can aggravate systemic inflammatory response. Therefore, CABG with non-extracorporeal circulation offers more beneficial outcomes.
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Base de dados:
MEDLINE
Assunto principal:
Ponte de Artéria Coronária
/
Circulação Extracorpórea
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article