Understanding V(D)J recombination initiator RAG1 gene using molecular phylogenetic and genetic variant analyses and upgrading missense and non-coding variants of clinical importance.

Kumar, Abhishek; Bhandari, Anita; Sarde, Sandeep J; Muppavarapu, Sekhar; Tandon, Ravi

Kumar, Abhishek; Bhandari, Anita; Sarde, Sandeep J; Muppavarapu, Sekhar; Tandon, Ravi.

Afiliação

Kumar A; Department of Genetics & Molecular Biology in Botany, Institute of Botany, Christian-Albrechts-University at Kiel, Kiel, Germany; Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany. Electronic address: abhishek.abhishekkumar@gmail.com.
Bhandari A; Molecular Physiology, Institute of Zoology, Christian-Albrechts-University at Kiel, Kiel, Germany.
Sarde SJ; Department of Genetics & Molecular Biology in Botany, Institute of Botany, Christian-Albrechts-University at Kiel, Kiel, Germany; Agrigenomics Program, Christian-Albrechts-University at Kiel, Kiel, Germany.
Muppavarapu S; Agrigenomics Program, Christian-Albrechts-University at Kiel, Kiel, Germany.
Tandon R; School of Biotechnology, Jawaharlal Nehru University, New Delhi, India. Electronic address: ravitandon@jnu.ac.in.

Biochem Biophys Res Commun ; 462(4): 301-13, 2015 Jul 10.

Article em En | MEDLINE | ID: mdl-25976673

Assuntos

Variação Genética; Proteínas de Homeodomínio/genética; Mutação de Sentido Incorreto; Filogenia; Recombinação V(D)J; Genoma Humano; Humanos; Íntrons; Spliceossomos

Palavras-chave

Ancestral locus; Missense variants; Non-coding variants; Phylogenetic analysis; RAG1; RAG1 variants

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Filogenia / Variação Genética / Proteínas de Homeodomínio / Mutação de Sentido Incorreto / Recombinação V(D)J Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google