PI3K-C2α: One enzyme for two products coupling vesicle trafficking and signal transduction.
FEBS Lett
; 589(14): 1552-8, 2015 Jun 22.
Article
em En
| MEDLINE
| ID: mdl-25979177
ABSTRACT
The spatial restriction of phosphorylated phosphoinositides generated downstream activated membrane receptors is critical for proper cell response to environmental cues. The α isoform of class II PI3Ks, PI3K-C2α, has emerged as a modulator of receptor localization, acting both in the control of receptor endocytosis and resensitization. This unexpectedly versatile enzyme was found to differentially produce two distinct 3-phosphorylated phosphoinositides and to selectively control distinct steps of vesicular traffic such as endocytosis and recycling. This review focuses on the latest discoveries regarding PI3K-C2α function in vesicle trafficking and its impact on cell biology and mammalian embryonic development.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Fosfatidilinositol 3-Quinases
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Transporte Proteico
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Isoenzimas
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article