Your browser doesn't support javascript.
loading
Complement Activation Correlates With Disease Severity and Contributes to Cytokine Responses in Plasmodium falciparum Malaria.
Berg, Aase; Otterdal, Kari; Patel, Sam; Gonca, Miguel; David, Catarina; Dalen, Ingvild; Nymo, Stig; Nilsson, Margareta; Nordling, Sofia; Magnusson, Peetra U; Ueland, Thor; Prato, Mauro; Giribaldi, Giuliana; Mollnes, Tom Eirik; Aukrust, Pål; Langeland, Nina; Nilsson, Per H.
Afiliação
  • Berg A; Department of Medicine, Stavanger University Hospital Department of Clinical Science, University of Bergen Department of Medicine, Central Hospital of Maputo, Mozambique.
  • Otterdal K; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet.
  • Patel S; Department of Medicine, Central Hospital of Maputo, Mozambique.
  • Gonca M; Department of Medicine, Central Hospital of Maputo, Mozambique.
  • David C; Department of Medicine, Central Hospital of Maputo, Mozambique.
  • Dalen I; Department of Research, Stavanger University Hospital.
  • Nymo S; Department of Immunology, Oslo University Hospital Rikshospitalet Research Laboratory Nordland Hospital, Bodø Faculty of Health Sciences, University of Tromsø, Norway.
  • Nilsson M; Department of Immunology, Oslo University Hospital Rikshospitalet.
  • Nordling S; Department of Immunology, Genetics, and Pathology, the Rudbeck Laboratory, Uppsala University, Sweden.
  • Magnusson PU; Department of Immunology, Genetics, and Pathology, the Rudbeck Laboratory, Uppsala University, Sweden.
  • Ueland T; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet K. G. Jebsen Inflammatory Research Center, University of Oslo Faculty of Medicine, University of Oslo K.G. Jebsen Thrombosis Research and Expertise Center, University of Tromsø, Norway.
  • Prato M; Department of Neuroscience, University of Torino, Italy Department of Public Health and Pediatric Sciences, University of Torino, Italy.
  • Giribaldi G; Department of Oncology, University of Torino, Italy.
  • Mollnes TE; Department of Immunology, Oslo University Hospital Rikshospitalet K. G. Jebsen Inflammatory Research Center, University of Oslo Faculty of Medicine, University of Oslo Research Laboratory Nordland Hospital, Bodø Faculty of Health Sciences, University of Tromsø, Norway.
  • Aukrust P; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet K. G. Jebsen Inflammatory Research Center, University of Oslo Faculty of Medicine, University of Oslo.
  • Langeland N; Department of Clinical Science, University of Bergen Department of Medicine, Haukeland University Hospital, Bergen.
  • Nilsson PH; Department of Immunology, Oslo University Hospital Rikshospitalet.
J Infect Dis ; 212(11): 1835-40, 2015 Dec 01.
Article em En | MEDLINE | ID: mdl-25980034
The impact of complement activation and its possible relation to cytokine responses during malaria pathology was investigated in plasma samples from patients with confirmed Plasmodium falciparum malaria and in human whole-blood specimens stimulated with malaria-relevant agents ex vivo. Complement was significantly activated in the malaria cohort, compared with healthy controls, and was positively correlated with disease severity and with certain cytokines, in particular interleukin 8 (IL-8)/CXCL8. This was confirmed in ex vivo-stimulated blood specimens, in which complement inhibition significantly reduced IL-8/CXCL8 release. P. falciparum malaria is associated with systemic complement activation and complement-dependent release of inflammatory cytokines, of which IL-8/CXCL8 is particularly prominent.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Citocinas / Malária Falciparum / Ativação do Complemento Limite: Adult / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Citocinas / Malária Falciparum / Ativação do Complemento Limite: Adult / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article