Protective effect of Wuzhi tablet (Schisandra sphenanthera extract) against cisplatin-induced nephrotoxicity via Nrf2-mediated defense response.

Jin, Jing; Li, Mei; Zhao, Zhongxiang; Sun, Xiaozhe; Li, Jia; Wang, Wenwen; Huang, Min; Huang, Zhiying

Jin, Jing; Li, Mei; Zhao, Zhongxiang; Sun, Xiaozhe; Li, Jia; Wang, Wenwen; Huang, Min; Huang, Zhiying.

Afiliação

Jin J; School of Pharmaceutical Sciences, Sun Yat-sen University, 132 East Circle at University City, Guangzhou 510006, PR China.
Li M; School of Pharmaceutical Sciences, Sun Yat-sen University, 132 East Circle at University City, Guangzhou 510006, PR China.
Zhao Z; School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
Sun X; School of Pharmaceutical Sciences, Sun Yat-sen University, 132 East Circle at University City, Guangzhou 510006, PR China.
Li J; Pharmaceutical Department, Cancer Center of Guangzhou Medical University, Guangzhou 510095, PR China.
Wang W; School of Pharmaceutical Sciences, Sun Yat-sen University, 132 East Circle at University City, Guangzhou 510006, PR China.
Huang M; School of Pharmaceutical Sciences, Sun Yat-sen University, 132 East Circle at University City, Guangzhou 510006, PR China.
Huang Z; School of Pharmaceutical Sciences, Sun Yat-sen University, 132 East Circle at University City, Guangzhou 510006, PR China. Electronic address: hzhiying@mail.sysu.edu.cn.

Phytomedicine ; 22(5): 528-35, 2015 May 15.

Article em En | MEDLINE | ID: mdl-25981918

Assuntos

Cisplatino/efeitos adversos; Medicamentos de Ervas Chinesas/farmacologia; Rim/efeitos dos fármacos; Fator 2 Relacionado a NF-E2/metabolismo; Animais; Antineoplásicos/efeitos adversos; Linhagem Celular; Glutamato-Cisteína Ligase/metabolismo; Glutationa/metabolismo; Heme Oxigenase-1/metabolismo; Humanos; Rim/patologia; Nefropatias/induzido quimicamente; Peroxidação de Lipídeos; Masculino; Camundongos; NAD(P)H Desidrogenase (Quinona)/metabolismo; Estresse Oxidativo; Espécies Reativas de Oxigênio/metabolismo; Schisandra/química; Comprimidos

Palavras-chave

Cisplatin; Nephrotoxicity; Nrf2; Schisandra sphenanthera; Wuzhi tablet

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Cisplatino / Fator 2 Relacionado a NF-E2 / Rim Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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