Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells.
Leuk Res Rep
; 4(1): 32-5, 2015.
Article
em En
| MEDLINE
| ID: mdl-25984443
ABSTRACT
In an mRNA profiling screen performed to unveil novel mechanisms of leukemogenesis, we found that the sentrin-specific protease 5 (SENP5) was significantly repressed in clinical acute myeloid leukemia when compared to healthy neutrophil samples. SENP5 is an enzyme that targets and cleaves small ubiquitin-like modifier (SUMO) residues from SUMOylated proteins. Further investigation with AML neutrophil differentiation cell models showed increased SENP5 expression upon induction of differentiation; in contrast, knocking down SENP5 resulted in significantly attenuated neutrophil differentiation. Our results support a new role of SENP5 in AML pathology, and in particular in the neutrophil differentiation of myeloid leukemic cells.
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MEDLINE
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En
Ano de publicação:
2015
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Article