B-cell-independent lymphoid tissue infection by a B-cell-tropic rhadinovirus.
J Gen Virol
; 96(9): 2788-2793, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-25986632
Lymphocytes provide gammaherpesviruses with a self-renewing substrate for persistent infection and with transport to mucosal sites for host exit. Their role in the initial colonization of new hosts is less clear. Murid herpesvirus 4 (MuHV-4), an experimentally accessible, B-cell-tropic rhadinovirus (gamma-2 herpesvirus), persistently infects both immunocompetent and B-cell-deficient mice. A lack of B-cells did not compromise MuHV-4 entry into lymphoid tissue, which involved myeloid cell infection. However, it impaired infection amplification and MuHV-4 exit from lymphoid tissue, which involved myeloid to B-cell transfer.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças dos Roedores
/
Linfócitos B
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Rhadinovirus
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Infecções por Herpesviridae
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Tecido Linfoide
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article