Outbreak of multidrug-resistant tuberculosis in two secondary schools.
Arch Bronconeumol
; 52(2): 70-5, 2016 Feb.
Article
em En, Es
| MEDLINE
| ID: mdl-25987369
ABSTRACT
OBJECTIVES:
To describe an outbreak of multidrug-resistant tuberculosis (MDR-TB) in two schoolsMETHODS:
This was a prospective, observational study of an outbreak of MDR-TB in 2 schools located in the towns of Onda and Nules, in the Spanish province of Castellon, from the moment of detection in November 2008 until November 2014, including patient follow-up and contact tracing.RESULTS:
Five cases of MDR-TB were diagnosed. Overall attack rate was 0.9%, and among the contacts traced, 66 had latent tuberculous infection, with an infection rate of 14.4%. Molecular characterization of the 5M. tuberculosis isolates was performed by restriction fragment length polymorphism (RFLP) analysis of the IS6110 sequence. In all 5 patients, cultures were negative at 4-month follow-up, showing the efficacy of the treatment given. No recurrence has been reported to date.CONCLUSIONS:
In the context of globalization and the increased prevalence of MDR-TB, outbreaks such as the one presented here are only to be expected. Contact tracing, strict follow-up of confirmed cases, the availability of fast diagnostic techniques to avoid treatment delay, and chemoprophylaxis, together with the molecular characterization of strains, are still essential.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Surtos de Doenças
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Tuberculose Resistente a Múltiplos Medicamentos
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Child
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Female
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Humans
/
Male
País como assunto:
Europa
Idioma:
En
/
Es
Ano de publicação:
2016
Tipo de documento:
Article