Investigating the Interaction Pattern and Structural Elements of a Drug-Polymer Complex at the Molecular Level.

Nie, Haichen; Mo, Huaping; Zhang, Mingtao; Song, Yang; Fang, Ke; Taylor, Lynne S; Li, Tonglei; Byrn, Stephen R

Nie, Haichen; Mo, Huaping; Zhang, Mingtao; Song, Yang; Fang, Ke; Taylor, Lynne S; Li, Tonglei; Byrn, Stephen R.

Afiliação

Nie H; Department of Industrial and Physical Pharmacy and Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.
Mo H; Department of Industrial and Physical Pharmacy and Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.
Zhang M; Department of Industrial and Physical Pharmacy and Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.
Song Y; Department of Industrial and Physical Pharmacy and Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.
Fang K; Department of Industrial and Physical Pharmacy and Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.
Taylor LS; Department of Industrial and Physical Pharmacy and Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.
Li T; Department of Industrial and Physical Pharmacy and Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.
Byrn SR; Department of Industrial and Physical Pharmacy and Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.

Mol Pharm ; 12(7): 2459-68, 2015 Jul 06.

Article em En | MEDLINE | ID: mdl-25988812

Assuntos

Clofazimina/química; Polímeros/química; Química Farmacêutica/métodos; Portadores de Fármacos/química; Composição de Medicamentos/métodos; Estabilidade de Medicamentos; Hansenostáticos/química; Metilcelulose/análogos & derivados; Metilcelulose/química; Solubilidade; Solventes/química

Palavras-chave

amorphous solid dispersion; clofazimine; drug loading capacity; drug polymer interactions; ionic interaction; solution NMR

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polímeros / Clofazimina Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polímeros / Clofazimina Idioma: En Ano de publicação: 2015 Tipo de documento: Article