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Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.
Mitra, Suman; Ring, Aaron M; Amarnath, Shoba; Spangler, Jamie B; Li, Peng; Ju, Wei; Fischer, Suzanne; Oh, Jangsuk; Spolski, Rosanne; Weiskopf, Kipp; Kohrt, Holbrook; Foley, Jason E; Rajagopalan, Sumati; Long, Eric O; Fowler, Daniel H; Waldmann, Thomas A; Garcia, K Christopher; Leonard, Warren J.
Afiliação
  • Mitra S; Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892-1674, USA.
  • Ring AM; Howard Hughes Medical Institute and Department of Molecular and Cellular Physiology and Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Amarnath S; Experimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Spangler JB; Howard Hughes Medical Institute and Department of Molecular and Cellular Physiology and Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Li P; Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892-1674, USA.
  • Ju W; Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, MD 20892-1374, USA.
  • Fischer S; Howard Hughes Medical Institute and Department of Molecular and Cellular Physiology and Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Oh J; Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892-1674, USA.
  • Spolski R; Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892-1674, USA.
  • Weiskopf K; Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Kohrt H; Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Foley JE; Experimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Rajagopalan S; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA.
  • Long EO; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA.
  • Fowler DH; Experimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Waldmann TA; Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, MD 20892-1374, USA.
  • Garcia KC; Howard Hughes Medical Institute and Department of Molecular and Cellular Physiology and Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: kcgarcia@stanford.edu.
  • Leonard WJ; Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892-1674, USA. Electronic address: wjl@helix.nih.gov.
Immunity ; 42(5): 826-38, 2015 May 19.
Article em En | MEDLINE | ID: mdl-25992859
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Engenharia de Proteínas / Receptores de Interleucina-2 / Transdução de Sinais / Interleucina-2 Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Engenharia de Proteínas / Receptores de Interleucina-2 / Transdução de Sinais / Interleucina-2 Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article