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The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis.
Van Roy, Maarten; Ververken, Cedric; Beirnaert, Els; Hoefman, Sven; Kolkman, Joost; Vierboom, Michel; Breedveld, Elia; 't Hart, Bert; Poelmans, Sofie; Bontinck, Lieselot; Hemeryck, Alex; Jacobs, Sandy; Baumeister, Judith; Ulrichts, Hans.
Afiliação
  • Van Roy M; Ablynx NV, Technologiepark 21, 9052, Zwijnaarde, Belgium. maarten.vanroy@ablynx.com.
  • Ververken C; Ablynx NV, Technologiepark 21, 9052, Zwijnaarde, Belgium. Cedric.Ververken@ablynx.com.
  • Beirnaert E; Ablynx NV, Technologiepark 21, 9052, Zwijnaarde, Belgium. beirnaerte@gmail.com.
  • Hoefman S; VIB, Rijvisschestraat 120, 9052, Zwijnaarde, Belgium. beirnaerte@gmail.com.
  • Kolkman J; Ablynx NV, Technologiepark 21, 9052, Zwijnaarde, Belgium. Sven.Hoefman@ablynx.com.
  • Vierboom M; Ablynx NV, Technologiepark 21, 9052, Zwijnaarde, Belgium. JKolkman@its.jnj.com.
  • Breedveld E; Crucell, Archimedesweg 4-6, 2333, CA, Leiden, The Netherlands. JKolkman@its.jnj.com.
  • 't Hart B; Department of Immunobiology, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ, Rijswijk, The Netherlands. vierboom@bprc.nl.
  • Poelmans S; Department of Immunobiology, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ, Rijswijk, The Netherlands. breedveld@bprc.nl.
  • Bontinck L; Department of Immunobiology, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ, Rijswijk, The Netherlands. hart@bprc.nl.
  • Hemeryck A; Department of Neuroscience, University of Groningen, University Medical Center, Hanzeplein 1, 9700 RB, Groningen, The Netherlands. hart@bprc.nl.
  • Jacobs S; Ablynx NV, Technologiepark 21, 9052, Zwijnaarde, Belgium. Sofie.Poelmans@ablynx.com.
  • Baumeister J; Ablynx NV, Technologiepark 21, 9052, Zwijnaarde, Belgium. Lieselot.Bontinck@ablynx.com.
  • Ulrichts H; Ablynx NV, Technologiepark 21, 9052, Zwijnaarde, Belgium. ahemeryc@gmail.com.
Arthritis Res Ther ; 17: 135, 2015 May 20.
Article em En | MEDLINE | ID: mdl-25994180
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Experimental / Anticorpos Biespecíficos / Antirreumáticos / Receptores de Interleucina-6 / Anticorpos de Domínio Único Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Experimental / Anticorpos Biespecíficos / Antirreumáticos / Receptores de Interleucina-6 / Anticorpos de Domínio Único Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article