Synergistically Enhanced Therapeutic Effect of a Carrier-Free HCPT/DOX Nanodrug on Breast Cancer Cells through Improved Cellular Drug Accumulation.

Chen, Fei; Zhao, Yuanyuan; Pan, Yuanming; Xue, Xiangdong; Zhang, Xu; Kumar, Anil; Liang, Xing-Jie

Chen, Fei; Zhao, Yuanyuan; Pan, Yuanming; Xue, Xiangdong; Zhang, Xu; Kumar, Anil; Liang, Xing-Jie.

Afiliação

Chen F; Laboratory of Controllable Nanopharmaceuticals, Chinese Academy of Sciences (CAS), Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No. 11, First North Road, Zhongguancun, Beijing 100190, China.
Zhao Y; University of Chinese Academy of Sciences, Beijing 100049, China.
Pan Y; Laboratory of Controllable Nanopharmaceuticals, Chinese Academy of Sciences (CAS), Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No. 11, First North Road, Zhongguancun, Beijing 100190, China.
Xue X; Laboratory of Controllable Nanopharmaceuticals, Chinese Academy of Sciences (CAS), Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No. 11, First North Road, Zhongguancun, Beijing 100190, China.
Zhang X; Laboratory of Controllable Nanopharmaceuticals, Chinese Academy of Sciences (CAS), Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No. 11, First North Road, Zhongguancun, Beijing 100190, China.
Kumar A; University of Chinese Academy of Sciences, Beijing 100049, China.
Liang XJ; Laboratory of Controllable Nanopharmaceuticals, Chinese Academy of Sciences (CAS), Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No. 11, First North Road, Zhongguancun, Beijing 100190, China.

Mol Pharm ; 12(7): 2237-44, 2015 Jul 06.

Article em En | MEDLINE | ID: mdl-25996761

Assuntos

Antibióticos Antineoplásicos/farmacologia; Neoplasias da Mama/tratamento farmacológico; Camptotecina/análogos & derivados; Doxorrubicina/farmacologia; Portadores de Fármacos/farmacologia; Nanopartículas/administração & dosagem; Camptotecina/farmacologia; Linhagem Celular Tumoral; Sistemas de Liberação de Medicamentos/métodos; Sinergismo Farmacológico; Feminino; Humanos; Células MCF-7

Palavras-chave

10-hydroxycamptothecin; doxorubicin; dual-drug nanoparticle; pure drug nanoparticle; synergistic therapy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Camptotecina / Portadores de Fármacos / Doxorrubicina / Nanopartículas / Antibióticos Antineoplásicos Limite: Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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