Designing the furin-cleavable linker in recombinant immunotoxins based on Pseudomonas exotoxin A.

Weldon, John E; Skarzynski, Martin; Therres, Jamy A; Ostovitz, Joshua R; Zhou, Hong; Kreitman, Robert J; Pastan, Ira

Weldon, John E; Skarzynski, Martin; Therres, Jamy A; Ostovitz, Joshua R; Zhou, Hong; Kreitman, Robert J; Pastan, Ira.

Afiliação

Weldon JE; Department of Biological Sciences, Jess and Mildred Fisher College of Science and Mathematics, Towson University, Towson, Maryland 21252, United States.
Skarzynski M; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.
Therres JA; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.
Ostovitz JR; Department of Biological Sciences, Jess and Mildred Fisher College of Science and Mathematics, Towson University, Towson, Maryland 21252, United States.
Zhou H; Department of Biological Sciences, Jess and Mildred Fisher College of Science and Mathematics, Towson University, Towson, Maryland 21252, United States.
Kreitman RJ; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.
Pastan I; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.

Bioconjug Chem ; 26(6): 1120-8, 2015 Jun 17.

Article em En | MEDLINE | ID: mdl-25997032

Assuntos

ADP Ribose Transferases/química; ADP Ribose Transferases/farmacologia; Antineoplásicos/química; Antineoplásicos/farmacologia; Toxinas Bacterianas/química; Toxinas Bacterianas/farmacologia; Exotoxinas/química; Exotoxinas/farmacologia; Furina/metabolismo; Imunotoxinas/química; Imunotoxinas/farmacologia; Fatores de Virulência/química; Fatores de Virulência/farmacologia; ADP Ribose Transferases/metabolismo; Sequência de Aminoácidos; Antineoplásicos/metabolismo; Toxinas Bacterianas/metabolismo; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Exotoxinas/metabolismo; Humanos; Imunotoxinas/metabolismo; Leucemia/tratamento farmacológico; Modelos Moleculares; Proteínas Recombinantes de Fusão/química; Proteínas Recombinantes de Fusão/metabolismo; Proteínas Recombinantes de Fusão/farmacologia; Fatores de Virulência/metabolismo; Exotoxina A de Pseudomonas aeruginosa

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Toxinas Bacterianas / Imunotoxinas / ADP Ribose Transferases / Fatores de Virulência / Furina / Exotoxinas / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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