Quantitative clinical pharmacology for size and age scaling in pediatric drug development: A systematic review.

Samant, Tanay S; Mangal, Naveen; Lukacova, Viera; Schmidt, Stephan

Samant, Tanay S; Mangal, Naveen; Lukacova, Viera; Schmidt, Stephan.

Afiliação

Samant TS; Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Lake Nona (Orlando), FL, USA.
Mangal N; Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Lake Nona (Orlando), FL, USA.
Lukacova V; Simulations Plus, Inc., Lancaster, CA, USA.
Schmidt S; Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Lake Nona (Orlando), FL, USA.

J Clin Pharmacol ; 55(11): 1207-17, 2015 Nov.

Article em En | MEDLINE | ID: mdl-26009792

Assuntos

Descoberta de Drogas; Farmacologia Clínica/métodos; Fatores Etários; Tamanho Corporal; Relação Dose-Resposta a Droga; Humanos; Modelos Biológicos; Farmacocinética

Palavras-chave

allometric scaling; pediatric drug development; physiologically-based pharmacokinetic modeling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Farmacologia Clínica / Descoberta de Drogas Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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