Selective Oxidation of Methionine and Tryptophan Residues in a Therapeutic IgG1 Molecule.

Folzer, Emilien; Diepold, Katharina; Bomans, Katrin; Finkler, Christof; Schmidt, Roland; Bulau, Patrick; Huwyler, Jörg; Mahler, Hanns-Christian; Koulov, Atanas V

Folzer, Emilien; Diepold, Katharina; Bomans, Katrin; Finkler, Christof; Schmidt, Roland; Bulau, Patrick; Huwyler, Jörg; Mahler, Hanns-Christian; Koulov, Atanas V.

Afiliação

Folzer E; Pharmaceutical Development and Supplies, Pharma Technical Development Biologics Europe, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Diepold K; Division of Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Bomans K; Analytical Development and Quality Control, Pharma Technical Development Biologics Europe, Roche Diagnostics GmbH, Penzberg, Germany.
Finkler C; Analytical Development and Quality Control, Pharma Technical Development Biologics Europe, Roche Diagnostics GmbH, Penzberg, Germany.
Schmidt R; Analytical Development and Quality Control, Pharma Technical Development Biologics Europe, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Bulau P; Pharmaceutical Development and Supplies, Pharma Technical Development Biologics Europe, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Huwyler J; Analytical Development and Quality Control, Pharma Technical Development Biologics Europe, Roche Diagnostics GmbH, Penzberg, Germany.
Mahler HC; Division of Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Koulov AV; Pharmaceutical Development and Supplies, Pharma Technical Development Biologics Europe, F. Hoffmann-La Roche Ltd., Basel, Switzerland.

J Pharm Sci ; 104(9): 2824-31, 2015 Sep.

Article em En | MEDLINE | ID: mdl-26010344

Assuntos

Imunoglobulina G/química; Metionina/química; Triptofano/química; Anticorpos Monoclonais/química; Peróxido de Hidrogênio/química; Indicadores e Reagentes; Metais/química; Oxirredução; Raios Ultravioleta

Palavras-chave

mass spectrometry; methionine; protein A binding; protein oxidation; therapeutic proteins; tryptophan

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triptofano / Imunoglobulina G / Metionina Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triptofano / Imunoglobulina G / Metionina Idioma: En Ano de publicação: 2015 Tipo de documento: Article