Muscle Satellite Cell Protein Teneurin-4 Regulates Differentiation During Muscle Regeneration.
Stem Cells
; 33(10): 3017-27, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26013034
ABSTRACT
Satellite cells are maintained in an undifferentiated quiescent state, but during muscle regeneration they acquire an activated stage, and initiate to proliferate and differentiate as myoblasts. The transmembrane protein teneurin-4 (Ten-4) is specifically expressed in the quiescent satellite cells; however, its cellular and molecular functions remain unknown. We therefore aimed to elucidate the function of Ten-4 in muscle satellite cells. In the tibialis anterior (TA) muscle of Ten-4-deficient mice, the number and the size of myofibers, as well as the population of satellite cells, were reduced with/without induction of muscle regeneration. Furthermore, we found an accelerated activation of satellite cells in the regenerated Ten-4-deficient TA muscle. The cell culture analysis using primary satellite cells showed that Ten-4 suppressed the progression of myogenic differentiation. Together, our findings revealed that Ten-4 functions as a crucial player in maintaining the quiescence of muscle satellite cells.
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Base de dados:
MEDLINE
Assunto principal:
Regeneração
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Diferenciação Celular
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Proliferação de Células
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Proteínas de Membrana
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article