Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs
; 7(4): 693-706, 2015.
Article
em En
| MEDLINE
| ID: mdl-26018625
Palavras-chave
BLAST, basic local alignment search tools; CDR; CDR, complementarity-determining region; FR; FR, framework region; HTG, High-Throughput Genomic database; IGHV, immunoglobulin heavy chain variable region gene; IGKV, immunoglobulin light chain kappa variable region gene; IGLV, immunoglobulin light chain lambda variable region gene; IgG; PDB, Protein Data Bank; V family/genes, variable region family/genes; VH, light chain variable region; Vκ, light chain kappa variable region; Vλ, light chain lambda variable region; WGS, Whole Genome Shotgun database; antibodies; biologics; camelid; canonical folds; germline variable genes; human sequence and structural homology; sequence mining
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Região Variável de Imunoglobulina
/
Homologia de Sequência de Aminoácidos
/
Dobramento de Proteína
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article