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Ribavirin Reduces Absolute Lymphocyte Counts in Hepatitis C Virus-Infected Patients Treated With Interferon-Free, Direct-Acting Antiviral Regimens.
Harrington, Patrick R; Fleischer, Russell; Connelly, Sarah M; Lewis, Linda L; Murray, Jeffrey.
Afiliação
  • Harrington PR; Division of Antiviral Products, Office of Antimicrobial Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
  • Fleischer R; Division of Antiviral Products, Office of Antimicrobial Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
  • Connelly SM; Division of Antiviral Products, Office of Antimicrobial Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
  • Lewis LL; Division of Antiviral Products, Office of Antimicrobial Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
  • Murray J; Division of Antiviral Products, Office of Antimicrobial Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
Clin Infect Dis ; 61(6): 974-7, 2015 Sep 15.
Article em En | MEDLINE | ID: mdl-26021996
In clinical trials of interferon-free, direct-acting antiviral treatment of chronic hepatitis C, subjects who received ribavirin had reduced lymphocyte levels (median decline of approximately 0.4-0.5 × 10(9) cells/L). A modest decline in CD4(+) T cells was observed in subjects with human immunodeficiency virus type 1 coinfection without documented opportunistic infections.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Ribavirina / Hepatite C Crônica / Linfopenia Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Ribavirina / Hepatite C Crônica / Linfopenia Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article