Anti-inflammatory Activity of Pyrrolizidine Alkaloids from the Leaves of Madhuca pasquieri (Dubard).
Chem Pharm Bull (Tokyo)
; 63(6): 481-4, 2015.
Article
em En
| MEDLINE
| ID: mdl-26027474
ABSTRACT
A novel pyrrolizidine alkaloids, madhumidine A (1), and two known alkaloids, lindelofidine benzoic acid ester (2) and minalobine B (3) were isolated from the leaves of Madhuca pasquieri (Dubard) H. J. LAM. The chemical structures of these alkaloids were established mainly by NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against lipopolysaccharide-induced nitric oxide production in macrophage RAW264.7 cell. In addition, the cytotoxic activity of all isolated compounds was tested against a panel of cancer cell lines.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Alcaloides de Pirrolizidina
/
Madhuca
/
Anti-Inflamatórios
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article