Brief Report: Human Mesenchymal Stem-Like Cells Facilitate Floating Tumorigenic Cell Growth via Glutamine-Ammonium Cycle.
Stem Cells
; 33(9): 2877-84, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-26031226
ABSTRACT
How mesenchymal stem cells (MSCs) promote tumor growth remains incompletely understood. Here, we show that mesenchymal stem-like cells (MSLCs) are commonly present in malignant pleural effusion or ascites of cancer patients, where they directly interact with tumor cells. Chemokines and chemokine receptors, especially the CCL2/CCR2 pathway, are involved in this interaction. As a result, MSLCs exert tumor-promoting effects by enhancing the proliferation and colony formation of tumor-repopulating cells. The underlying molecular basis involves MSLC release of glutamine to tumorigenic cells. Inhibition of glutamine uptake impedes MSC-mediated tumor-promoting effects. More intriguingly, MSLCs take up tumor cell-released ammonium that, in turn, favors MSLC growth. Thus, glutamine and ammonium form a vicious cycle between MSLCs and tumorigenic cells. These findings suggest a potential clinical application by targeting MSLCs in patients with malignant pleural effusions or ascites.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Proliferação de Células
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Células-Tronco Mesenquimais
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Carcinogênese
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Compostos de Amônio
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Glutamina
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article