[New era in the treatment of chronic hepatitis C - novel direct acting antivirals]. / Korszakváltás a krónikus C-vírus hepatitis terápiájában - új direkt ható antivirális szerek.
Orv Hetil
; 156(21): 841-8, 2015 May 24.
Article
em Hu
| MEDLINE
| ID: mdl-26038991
Chronic hepatitis C, without treatment, can cause liver cirrhosis, liver failure and liver cancer. The availability of new oral direct acting antivirals, such as the protease inhibitors simeprevir, asunaprevir and paritaprevir, the NS5A inhibitors daclatasvir, ledipasvir, and ombitasvir, the polymerase inhibitors Sofosbuvir and dasabuvir have resulted an enormous progress in the treatment of chronic hepatitis C, leading to >90% sustained viral response rates. Even the hard-to-treat or previously treatment ineligible patients can be cured with the combination of these drugs. Furthermore the treatment duration is much shorter, and the side effects are minimal. Today, treatment of all hepatitis C virus infected patients is recommended, and the best choices are the interferon-free options. Eradication of hepatitis C virus has become realistic, however, appropriate screening programs are mandatory to achieve this goal.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Inibidores de Proteases
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Replicação Viral
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Proteínas não Estruturais Virais
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Hepacivirus
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Inibidores da Síntese de Ácido Nucleico
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Hepatite C Crônica
Idioma:
Hu
Ano de publicação:
2015
Tipo de documento:
Article