The triglyceride-lowering effect of supplementation with dual probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032: Reduction of fasting plasma lysophosphatidylcholines in nondiabetic and hypertriglyceridemic subjects.
Nutr Metab Cardiovasc Dis
; 25(8): 724-33, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-26044516
ABSTRACT
BACKGROUND AND AIMS:
This study evaluated the triglyceride (TG)-lowering effects of consuming dual probiotic strains of Lactobacillus curvatus (L. curvatus) HY7601 and Lactobacillus plantarum (L. plantarum) KY1032 on the fasting plasma metabolome. METHODS ANDRESULTS:
A randomized, double-blind, placebo-controlled study was conducted on 92 participants with hypertriglyceridemia but without diabetes. Over a 12-week testing period, the probiotic group consumed 2 g of powder containing 5 × 10(9) colony-forming units (cfu) of L. curvatus HY7601 and 5 × 10(9) cfu of L. plantarum KY1032 each day, whereas the placebo group consumed the same product without probiotics. Fasting plasma metabolomes were profiled using UPLC-LTQ-Orbitrap MS. After 12 weeks of treatment, the probiotic group displayed a 20% reduction (p = 0.001) in serum TGs and 25% increases (p=0.001) in apolipoprotein A-V (apoA-V). At the 12-week follow-up assessment, the following 11 plasma metabolites were significantly reduced in the probiotic group than the placebo group palmitoleamide, palmitic amide, oleamide, and lysophosphatidyl choline (lysoPC) containing C140, C161, C160, C170, C183, C182, C181, and C203. In the probiotic group, changes (âµ) in TG were negatively correlated with âµ apoA-V, which was positively correlated with âµ FFA. In addition, âµ FFA was strongly and positively correlated with âµ lysoPCs in the probiotic group but not the placebo group.CONCLUSIONS:
The triglyceride-lowering effects of probiotic supplementation, partly through elevated apoA-V, in borderline to moderate hypertriglyceridemic subjects showed reductions in plasma metabolites, fatty acid primary amides and lysoPCs (NCT02215694; http//www.clinicaltrials.gov). Clinical trials NCT02215694; http//www.clinicaltrials.gov.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lisofosfatidilcolinas
/
Hipertrigliceridemia
/
Probióticos
/
Lactobacillus plantarum
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article