Structural Basis of Clade-specific Engagement of SAMHD1 (Sterile &#945; Motif and Histidine/Aspartate-containing Protein 1) Restriction Factors by Lentiviral Viral Protein X (Vpx) Virulence Factors.

Wu, Ying; Koharudin, Leonardus M I; Mehrens, Jennifer; DeLucia, Maria; Byeon, Chang-Hyeok; Byeon, In-Ja L; Calero, Guillermo; Ahn, Jinwoo; Gronenborn, Angela M

Structural Basis of Clade-specific Engagement of SAMHD1 (Sterile α Motif and Histidine/Aspartate-containing Protein 1) Restriction Factors by Lentiviral Viral Protein X (Vpx) Virulence Factors.

Wu, Ying; Koharudin, Leonardus M I; Mehrens, Jennifer; DeLucia, Maria; Byeon, Chang-Hyeok; Byeon, In-Ja L; Calero, Guillermo; Ahn, Jinwoo; Gronenborn, Angela M.

Afiliação

Wu Y; Department of Structural Biology and Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260.
Koharudin LMI; Department of Structural Biology and Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260.
Mehrens J; Department of Structural Biology and Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260.
DeLucia M; Department of Structural Biology and Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260.
Byeon CH; Department of Structural Biology and Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260.
Byeon IL; Department of Structural Biology and Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260.
Calero G; Department of Structural Biology and Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260.
Ahn J; Department of Structural Biology and Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260. Electronic address: jia12@pitt.edu.
Gronenborn AM; Department of Structural Biology and Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260. Electronic address: amg100@pitt.edu.

J Biol Chem ; 290(29): 17935-17945, 2015 Jul 17.

Article em En | MEDLINE | ID: mdl-26045556

Assuntos

Interações Hospedeiro-Patógeno; Infecções por Lentivirus/metabolismo; Lentivirus/fisiologia; Proteínas Monoméricas de Ligação ao GTP/metabolismo; Proteínas Virais Reguladoras e Acessórias/metabolismo; Fatores de Virulência/metabolismo; Sequência de Aminoácidos; Animais; Cristalografia por Raios X; Células HEK293; Humanos; Infecções por Lentivirus/virologia; Simulação de Acoplamento Molecular; Dados de Sequência Molecular; Proteínas Monoméricas de Ligação ao GTP/química; Estrutura Terciária de Proteína; Proteína 1 com Domínio SAM e Domínio HD; Alinhamento de Sequência; Proteínas Virais Reguladoras e Acessórias/química

Palavras-chave

SAM domain and HD domain-containing protein 1 (SAMHD1); SIV; X-ray crystallography; human immunodeficiency virus (HIV); nuclear magnetic resonance (NMR); restriction factor; ubiquitylation (ubiquitination)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Lentivirus / Lentivirus / Proteínas Monoméricas de Ligação ao GTP / Fatores de Virulência / Proteínas Virais Reguladoras e Acessórias / Interações Hospedeiro-Patógeno Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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