Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.

Bédard, Nathalie; Jammoul, Samer; Moore, Tamara; Wykes, Linda; Hallauer, Patricia L; Hastings, Kenneth E M; Stretch, Cynthia; Baracos, Vickie; Chevalier, Stéphanie; Plourde, Marie; Coyne, Erin; Wing, Simon S

Bédard, Nathalie; Jammoul, Samer; Moore, Tamara; Wykes, Linda; Hallauer, Patricia L; Hastings, Kenneth E M; Stretch, Cynthia; Baracos, Vickie; Chevalier, Stéphanie; Plourde, Marie; Coyne, Erin; Wing, Simon S.

Afiliação

Bédard N; *Polypeptide Laboratory and Crabtree Nutrition Laboratories, Department of Medicine, McGill University Health Centre, and Molecular Genetics Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; School of Dietetics and Human Nutrition, McGill University, Ste-Anne-
Jammoul S; *Polypeptide Laboratory and Crabtree Nutrition Laboratories, Department of Medicine, McGill University Health Centre, and Molecular Genetics Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; School of Dietetics and Human Nutrition, McGill University, Ste-Anne-
Moore T; *Polypeptide Laboratory and Crabtree Nutrition Laboratories, Department of Medicine, McGill University Health Centre, and Molecular Genetics Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; School of Dietetics and Human Nutrition, McGill University, Ste-Anne-
Wykes L; *Polypeptide Laboratory and Crabtree Nutrition Laboratories, Department of Medicine, McGill University Health Centre, and Molecular Genetics Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; School of Dietetics and Human Nutrition, McGill University, Ste-Anne-
Hallauer PL; *Polypeptide Laboratory and Crabtree Nutrition Laboratories, Department of Medicine, McGill University Health Centre, and Molecular Genetics Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; School of Dietetics and Human Nutrition, McGill University, Ste-Anne-
Hastings KE; *Polypeptide Laboratory and Crabtree Nutrition Laboratories, Department of Medicine, McGill University Health Centre, and Molecular Genetics Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; School of Dietetics and Human Nutrition, McGill University, Ste-Anne-
Stretch C; *Polypeptide Laboratory and Crabtree Nutrition Laboratories, Department of Medicine, McGill University Health Centre, and Molecular Genetics Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; School of Dietetics and Human Nutrition, McGill University, Ste-Anne-
Baracos V; *Polypeptide Laboratory and Crabtree Nutrition Laboratories, Department of Medicine, McGill University Health Centre, and Molecular Genetics Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; School of Dietetics and Human Nutrition, McGill University, Ste-Anne-
Chevalier S; *Polypeptide Laboratory and Crabtree Nutrition Laboratories, Department of Medicine, McGill University Health Centre, and Molecular Genetics Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; School of Dietetics and Human Nutrition, McGill University, Ste-Anne-
Plourde M; *Polypeptide Laboratory and Crabtree Nutrition Laboratories, Department of Medicine, McGill University Health Centre, and Molecular Genetics Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; School of Dietetics and Human Nutrition, McGill University, Ste-Anne-
Coyne E; *Polypeptide Laboratory and Crabtree Nutrition Laboratories, Department of Medicine, McGill University Health Centre, and Molecular Genetics Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; School of Dietetics and Human Nutrition, McGill University, Ste-Anne-
Wing SS; *Polypeptide Laboratory and Crabtree Nutrition Laboratories, Department of Medicine, McGill University Health Centre, and Molecular Genetics Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; School of Dietetics and Human Nutrition, McGill University, Ste-Anne-

FASEB J ; 29(9): 3889-98, 2015 Sep.

Article em En | MEDLINE | ID: mdl-26048142

Assuntos

Endopeptidases/metabolismo; Proteínas Musculares/metabolismo; Atrofia Muscular/metabolismo; Proteínas Ligases SKP Culina F-Box/biossíntese; Ubiquitina-Proteína Ligases/biossíntese; Idoso; Animais; Endopeptidases/genética; Feminino; Neoplasias Gastrointestinais/genética; Neoplasias Gastrointestinais/metabolismo; Humanos; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/metabolismo; Masculino; Camundongos; Camundongos Knockout; Pessoa de Meia-Idade; Proteínas Musculares/biossíntese; Proteínas Musculares/genética; Músculo Esquelético/metabolismo; Atrofia Muscular/genética; Proteínas Ligases SKP Culina F-Box/genética; Proteínas com Motivo Tripartido; Ubiquitina-Proteína Ligases/genética

Palavras-chave

cachexia; deubiquitylation; sarcopenia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Endopeptidases / Atrofia Muscular / Ubiquitina-Proteína Ligases / Proteínas Ligases SKP Culina F-Box / Proteínas Musculares Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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