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Discovery of biaryl carboxylamides as potent RORγ inverse agonists.
Chao, Jianhua; Enyedy, Istvan; Van Vloten, Kurt; Marcotte, Douglas; Guertin, Kevin; Hutchings, Richard; Powell, Noel; Jones, Howard; Bohnert, Tonika; Peng, Chi-Chi; Silvian, Laura; Hong, Victor Sukbong; Little, Kevin; Banerjee, Daliya; Peng, Liaomin; Taveras, Arthur; Viney, Joanne L; Fontenot, Jason.
Afiliação
  • Chao J; Chemical and Molecular Therapeutics, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States. Electronic address: jianhua.chao@gmail.com.
  • Enyedy I; Chemical and Molecular Therapeutics, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States.
  • Van Vloten K; Chemical and Molecular Therapeutics, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States.
  • Marcotte D; Chemical and Molecular Therapeutics, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States.
  • Guertin K; Chemical and Molecular Therapeutics, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States.
  • Hutchings R; Chemical and Molecular Therapeutics, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States.
  • Powell N; Chemical and Molecular Therapeutics, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States.
  • Jones H; Chemical and Molecular Therapeutics, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States.
  • Bohnert T; Chemical and Molecular Therapeutics, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States.
  • Peng CC; Chemical and Molecular Therapeutics, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States.
  • Silvian L; Chemical and Molecular Therapeutics, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States.
  • Hong VS; Chemical and Molecular Therapeutics, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States.
  • Little K; Chemical and Molecular Therapeutics, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States.
  • Banerjee D; Immunology Research, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States.
  • Peng L; Immunology Research, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States.
  • Taveras A; Chemical and Molecular Therapeutics, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States.
  • Viney JL; Immunology Research, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States.
  • Fontenot J; Immunology Research, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States.
Bioorg Med Chem Lett ; 25(15): 2991-7, 2015 Aug 01.
Article em En | MEDLINE | ID: mdl-26048806
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Bifenilo / Agonismo Inverso de Drogas / Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares / Amidas Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Bifenilo / Agonismo Inverso de Drogas / Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares / Amidas Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article