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Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations.
Dehay, Benjamin; Bourdenx, Mathieu; Gorry, Philippe; Przedborski, Serge; Vila, Miquel; Hunot, Stephane; Singleton, Andrew; Olanow, C Warren; Merchant, Kalpana M; Bezard, Erwan; Petsko, Gregory A; Meissner, Wassilios G.
Afiliação
  • Dehay B; Institute of Neurodegenerative Diseases, University of Bordeaux, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5293, 33076 Bordeaux, France.
  • Bourdenx M; Institute of Neurodegenerative Diseases, University of Bordeaux, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5293, 33076 Bordeaux, France.
  • Gorry P; Research Unit of Theoretical & Applied Economics, University of Bordeaux, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5113, 33608 Pessac, France.
  • Przedborski S; Departments of Neurology, Pathology and Cell Biology, and the Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.
  • Vila M; Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas, 08035 Barcelona, Spain.
  • Hunot S; Department of Biochemistry and Molecular Biology, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain.
  • Singleton A; Catalan Institution for Research and Advanced Studies, 08010 Barcelona, Spain.
  • Olanow CW; ICM, Paris, France; Sorbonne Universités.
  • Merchant KM; UPMC Université Paris 06, UM 75, ICM, Paris, France.
  • Bezard E; CNRS, UMR 7225, ICM, Paris, France.
  • Petsko GA; Inserm, U 1127, ICM, Paris, France.
  • Meissner WG; Molecular Genetics Section and Laboratory of Neurogenetics, NIA, NIH, Bethesda, MD20892, USA.
Lancet Neurol ; 14(8): 855-866, 2015 Aug.
Article em En | MEDLINE | ID: mdl-26050140
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Alfa-Sinucleína / Descoberta de Drogas Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Alfa-Sinucleína / Descoberta de Drogas Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article