The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.

Wood, Edgar R; Bledsoe, Randy; Chai, Jing; Daka, Philias; Deng, Hongfeng; Ding, Yun; Harris-Gurley, Sarah; Kryn, Luz Helena; Nartey, Eldridge; Nichols, James; Nolte, Robert T; Prabhu, Ninad; Rise, Cecil; Sheahan, Timothy; Shotwell, J Brad; Smith, Danielle; Tai, Vince; Taylor, J David; Tomberlin, Ginger; Wang, Liping; Wisely, Bruce; You, Shihyun; Xia, Bing; Dickson, Hamilton

Wood, Edgar R; Bledsoe, Randy; Chai, Jing; Daka, Philias; Deng, Hongfeng; Ding, Yun; Harris-Gurley, Sarah; Kryn, Luz Helena; Nartey, Eldridge; Nichols, James; Nolte, Robert T; Prabhu, Ninad; Rise, Cecil; Sheahan, Timothy; Shotwell, J Brad; Smith, Danielle; Tai, Vince; Taylor, J David; Tomberlin, Ginger; Wang, Liping; Wisely, Bruce; You, Shihyun; Xia, Bing; Dickson, Hamilton.

Afiliação

Wood ER; From the Departments of Biological Sciences and edgar.r.wood@mindspring.com.
Bledsoe R; From the Departments of Biological Sciences and.
Chai J; ELT Boston, GlaxoSmithKline, Waltham, Massachusetts 02451.
Daka P; Antiviral Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, North Carolina 27709 and.
Deng H; ELT Boston, GlaxoSmithKline, Waltham, Massachusetts 02451.
Ding Y; ELT Boston, GlaxoSmithKline, Waltham, Massachusetts 02451.
Harris-Gurley S; From the Departments of Biological Sciences and.
Kryn LH; From the Departments of Biological Sciences and.
Nartey E; From the Departments of Biological Sciences and.
Nichols J; From the Departments of Biological Sciences and.
Nolte RT; Chemical Sciences.
Prabhu N; ELT Boston, GlaxoSmithKline, Waltham, Massachusetts 02451.
Rise C; ELT Boston, GlaxoSmithKline, Waltham, Massachusetts 02451.
Sheahan T; Antiviral Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, North Carolina 27709 and.
Shotwell JB; Antiviral Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, North Carolina 27709 and.
Smith D; From the Departments of Biological Sciences and.
Tai V; Antiviral Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, North Carolina 27709 and.
Taylor JD; From the Departments of Biological Sciences and.
Tomberlin G; From the Departments of Biological Sciences and.
Wang L; Chemical Sciences.
Wisely B; From the Departments of Biological Sciences and.
You S; Antiviral Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, North Carolina 27709 and.
Xia B; ELT Boston, GlaxoSmithKline, Waltham, Massachusetts 02451.
Dickson H; Antiviral Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, North Carolina 27709 and.

J Biol Chem ; 290(32): 19681-96, 2015 Aug 07.

Article em En | MEDLINE | ID: mdl-26055709

Assuntos

2',5'-Oligoadenilato Sintetase/imunologia; Antivirais/farmacologia; Endorribonucleases/imunologia; Exorribonucleases/química; Imunidade Inata; Bibliotecas de Moléculas Pequenas/farmacologia; 2',5'-Oligoadenilato Sintetase/genética; Nucleotídeos de Adenina/imunologia; Nucleotídeos de Adenina/metabolismo; Antivirais/síntese química; Cristalografia por Raios X; Vírus da Encefalomiocardite/genética; Vírus da Encefalomiocardite/metabolismo; Endorribonucleases/genética; Escherichia coli/genética; Escherichia coli/metabolismo; Exorribonucleases/antagonistas & inibidores; Exorribonucleases/genética; Exorribonucleases/imunologia; Regulação da Expressão Gênica; Técnicas de Inativação de Genes; Células HeLa; Humanos; Interferon-alfa/farmacologia; Modelos Moleculares; Oligorribonucleotídeos/imunologia; Oligorribonucleotídeos/metabolismo; Poli I-C/farmacologia; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/imunologia; Vírus Sinciciais Respiratórios/genética; Vírus Sinciciais Respiratórios/metabolismo; Rhinovirus/genética; Rhinovirus/metabolismo; Transdução de Sinais; Bibliotecas de Moléculas Pequenas/síntese química; Relação Estrutura-Atividade

Palavras-chave

antiviral agent; gene knockout; innate immunity; interferon; protein structure

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / 2',5'-Oligoadenilato Sintetase / Endorribonucleases / Exorribonucleases / Bibliotecas de Moléculas Pequenas / Imunidade Inata Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google